HPE Partners with Los Alamos National Laboratory and NVIDIA to Deliver Next-Gen Supercomputers

In a significant development for both scientific research and national security, Hewlett Packard Enterprise Co (HPE) announced on October 28, 2025, its selection to build two state-of-the-art supercomputers, "Mission" and "Vision", for the Los Alamos National Laboratory (LANL). This initiative, part of a broader collaboration with the U.S. Department of Energy (DOE) and the National Nuclear Security Administration (NNSA), aims to bolster capabilities in artificial intelligence (AI) and enhance national security efforts.

The deployment of the Mission and Vision supercomputers is part of the DOE's ambitious $370 million investment plan to accelerate scientific discovery and advance AI initiatives. These systems will leverage the cutting-edge HPE Cray Supercomputing GX5000 architecture and include the upcoming NVIDIA Vera Rubin Superchips, designed to meet the growing demands of computational science in the AI era.

Trish Damkroger, senior vice president and general manager of HPC & AI Infrastructure Solutions at HPE, commented on the long-standing collaboration between HPE and LANL. “For decades, HPE and Los Alamos National Laboratory have collaborated on innovative supercomputing designs that deliver powerful capabilities to solve complex scientific challenges and bolster national security efforts,” she stated.

The Mission supercomputer is set to be a game-changer, boasting capabilities four times faster than LANL's current Crossroads system. It will provide enhanced AI, modeling, and simulation capabilities critical to the NNSA’s security initiatives. Brandon Williams, NNSA Administrator, emphasized the significance of this endeavor for maintaining America's leadership in the global AI race, stating that the new supercomputers will incorporate cutting-edge capabilities essential for effective national security.

Vision will build on the success of the HPE-built Venado supercomputer, which initially served unclassified research purposes. This new system promises a substantial upgrade in computational capabilities, particularly for AI-driven research, aligning with LANL’s mission to tackle pressing global challenges.

Both Mission and Vision will utilize the advanced HPE Cray Supercomputing GX5000, NVIDIA Vera Rubin GPUs, and NVIDIA Quantum-X800 InfiniBand networking. The GX5000 architecture is purpose-built for exascale computing, enhancing research output through multi-tenant capabilities. According to HPE, this new architecture offers 25% more density compared to its predecessor, allowing for greater flexibility and efficiency in research.

Ian Buck, vice president of hyperscale and high-performance computing at NVIDIA, expressed excitement about the project, noting that with the capabilities of Mission and Vision, LANL is poised to advance the frontiers of simulation and generative intelligence.

The systems will be unveiled at the NVIDIA GTC DC event, where officials from the U.S. DOE, NNSA, LANL, HPE, and NVIDIA will discuss the groundbreaking capabilities of these supercomputers. This event marks a pivotal moment in the collaboration between public and private sectors to drive innovation in AI and national security.

The partnership between HPE, LANL, and NVIDIA represents a transformative step in supercomputing technology aimed at enhancing AI research and national security. As the world increasingly relies on advanced computational capabilities, the Mission and Vision supercomputers will provide essential tools for researchers and policymakers alike, ensuring that the United States remains at the forefront of scientific discovery and innovation.